You need direct connectivity from an on-premises network to SAP HANA (Large Instances). The solution must meet the following requirements:

Minimize administrative effort.
Provide the highest level of resiliency.

What should you use?

A. ExpressRoute Global Reach
B. Linux IPTables

C. ExpressRoute

D. NGINX as a reverse proxy

Explanation:
The Azure network functionality used is:
Azure virtual networks are connected to the ExpressRoute circuit that connects to your on-premises network assets.
An ExpressRoute circuit that connects on-premises to Azure should have a minimum bandwidth of 1 Gbps or higher. This minimal bandwidth allows adequate bandwidth for the transfer of data between on-premises systems and systems that run on VMs. It also allows adequate bandwidth for connection to Azure systems from on-premises users.
All SAP systems in Azure are set up in virtual networks to communicate with each other.

References:
https://docs.microsoft.com/en-us/azure/virtual-machines/workloads/sap/hana-network-architecture