In ATM:

A.
Both VPI and VCI have end-to-end significance.

B.
VPI has end to end significance while VCI has local significance.

C.
VPI has only local significance while VCI has end-to-end significance.

D.
Both VPI and VCI have only local significance.

Explanation:
The most important fields in all three ATM cell header types are:
* Virtual Path Identifier (VPI)
The VPI identifies the route (path) to be taken by the ATM cell
* Virtual Circuit Identifier (VCI)
the VCI identifies the circuit or connection number on that path. The VPI and VCI are translated at each ATM switch, they are unique only for a given physical link.